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Sodium valproate and valproic acid surface to decrease barbiturate metabolism; therefore, barbiturate blood concentrations must be monitored and correct dosage changes created as indicated.

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Hold this medication during the container it came in, tightly shut, and away from attain of children. Store it at space temperature and away from excess heat and moisture (not in the lavatory).

Tolerance is usually a condition of adaptation through which exposure into a drug induces variations that lead to a diminution of a number of with the drug’s effects as time passes. Tolerance may possibly arise to the two the desired and undesired consequences of medication and should develop at distinct premiums for various consequences.

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Butalbital was found in the infant's serum. The toddler was supplied phenobarbital five mg/kg, which was tapered devoid of further more seizure or other withdrawal indications.

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